Humanoids

Feral Ghouls

Mutants

Once human, now horribly mutated. Super Mutants are by and large insane, but retain speech and are able to use firearms and melee weapons.

Strategies

Super Mutant – Super Mutants are thick-skinned and coming armed with a variety of weapons, so they are a challenge. If they wield a melee weapon, you should cripple their legs to slow their advance, while if they hold a gun, target the gun in VATS to make them drop it. Then just deal as much damage as possible, as they take the same damage everywhere.

Nightkin – Nightkin are Super Mutants that can turn invisible. They should be dealt with similarly, with the proviso that if they turn invisible, you need to attack them outside of VATS to make them targetable.

Humanoids

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